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Nuclear lamina, its function in the cell and its role in interaction with non-enveloped DNA viruses
Pápež, Samuel ; Bruštíková, Kateřina (advisor) ; Kuthan, Martin (referee)
The nuclear lamina is a protein network found in all metazoa. It is composed of intermediate filaments V, namely type A and type B lamins. It is a multifunctional cellular structure adjacent to the inner nuclear membrane, giving the nucleus its shape, ensuring its mechanical stability and participating in the regulation of many nuclear processes. The nuclear lamina also has a protective function manifested in the infection of cells with DNA viruses, whose life cycle takes place in the nucleoplasm. These include small non-enveloped DNA viruses. The nuclear lamina is an obstacle that viruses have had to learn to overcome in order to multiply. To do this, they use their own, but also cellular mechanisms, which disrupt the nuclear membrane together with the nuclear lamina and thus allow the virus nuclear entry and exit. This work summarizes the knowledge about changes in the nuclear lamina induced by viruses of the families Polyomaviridae, Parvoviridae and Circoviridae, on the way through the nuclear envelope. Keywords: Nuclear lamina, disassembly of nuclear lamina, DNA viruses, Polyomaviruses, Parvoviruses, Circoviruses
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